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[10] Diagnosis is not always straightforward and can be challenging and can take up to several years to receive a diagnosis from the onset of symptoms and almost 60% of those affected are misdiagnosed or not initially diagnosed at all

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Intense research in this field culminated with the discovery of the role of the protein nicotinamide phosphoribosyltransferase (Nampt) (also known as visfatin or PBEF) as a key enzyme involved in de novo synthesis of NAD [15]

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